12 Mar 2020 CHF 6001 is a highly potent PDE4 inhibitor (IC50 = 0.026 nM) that showed preclinical efficacy in a variety of species (Moretto et al., 2015;
CHF-6001 is a novel PDE4 inhibitor designed for treating pulmonary inflammatory diseases via inhaled administration. CHF6001 was 7- and 923-fold more potent than roflumilast and cilomilast, respectively, in inhibiting PDE4 enzymatic activity (IC50 = 0.026 ± 0.006 nM).
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Chf-6001 | C30H30Cl2F2N2O8S | CID 70662473 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities
It is an object of precision and Art for esthetes. Remember those crazy time travel contraptions, with all … 6,217 USD/CHF - 6,217 US Dollar to Swiss Franc. As of 15 April 2021, the current exchange rate of 6217 US Dollar is equal to 5,738.38 Swiss Franc. This is a decrease of -4.380801% (or -262.904 CHF) compared with the same time last year (15 April 2020), when 6217 US Dollar equaled 6,001… Chf-6001 | C30H30Cl2F2N2O8S | CID 70662473 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities CHF-6001 is a novel PDE4 inhibitor designed for treating pulmonary inflammatory diseases via inhaled administration. CHF6001 was 7- and 923-fold more potent than roflumilast and cilomilast, respectively, in inhibiting PDE4 enzymatic activity (IC50 = 0.026 ± 0.006 nM). For the biopharma industry investment, business development and competitive intelligence professionals who require information to support financing, partnering and licensing activities, BCIQ provides accurate information and context to support profitable and strategic decision making.
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CH The PDE4 inhibitor CHF-6001 and LAMAs inhibit bronchoconstriction-induced remodeling in lung slices.
CHF6001 was 7- and 923-fold more potent than roflumilast and cilomilast, respectively, in inhibiting PDE4 enzymatic activity (IC50 = 0.026 +/- 0.006 nM).
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4. CHF 6001 was metabolized through hydrolysis with the formation of the alcohol CHF 5956, loss of a chlorine atom, loss of the N-oxide, hydroxylation, loss of the cyclopropylmethyl group in the alcohol moiety, conjugation with glucuronic acid, glutathione and cysteine–glycine. 5.
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CHF-6001 is in phase II clinical trials by Chiesi Farmaceutici for the treatment of asthma and chronic obstructive pulmonary disease (COPD).
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The metabolism of CHF 6001, a novel PDE4 inhibitor, was determined in vitro in mouse, rat, dog, monkey and human microsomes and hepatocytes and in vivo
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A phase I randomised, double-blind, placebo-controlled study of single and repeated ascending doses in healthy volunteers to investigate the safety, tolerability and pharmacokinetics of inhaled CHF 6001.